(2024)
Soluble receptors in cancer: mechanisms, clinical significance, and therapeutic strategies.
EXPERIMENTAL AND MOLECULAR MEDICINE.
56,
1
(2023)
Pellino-1 expression is associated with epidermal proliferation and enhanced Th17 cell infiltration in psoriatic lesions.
EXPERIMENTAL DERMATOLOGY.
32,
9
(2023)
Ubiquitination Links DNA Damage and Repair Signaling to Cancer Metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.
24,
9
(2023)
Phosphatase Ssu72 Is Essential for Homeostatic Balance Between CD4+T Cell Lineages.
IMMUNE NETWORK.
23,
2
(2023)
Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation.
NATURE COMMUNICATIONS.
14,
1
(2022)
Protein phosphatases regulate the liver microenvironment in the development of hepatocellular carcinoma.
EXPERIMENTAL AND MOLECULAR MEDICINE.
54,
11
(2022)
The Pellino1-PKC theta Signaling Axis Is an Essential Target for Improving Antitumor CD8(+) T-lymphocyte Function.
CANCER IMMUNOLOGY RESEARCH.
10,
3
(2022)
Mammalian Ssu72 phosphatase preferentially considers tissue-specific actively transcribed gene expression by regulating RNA Pol II transcription.
THERANOSTICS.
12,
1
(2021)
Ssu72-HNF4 alpha signaling axis classify the transition from steatohepatitis to hepatocellular carcinoma.
CELL DEATH AND DIFFERENTIATION.
29,
3
(2021)
Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing inflammation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
118,
35
(2021)
Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells.
CELLULAR & MOLECULAR IMMUNOLOGY.
18,
6
(2019)
De novo phosphorylation of H2AX by WSTF regulates transcription-coupled homologous recombination repair.
NUCLEIC ACIDS RESEARCH.
47,
12
(2019)
Pellino1 regulates reversible ATM activation via NBS1 ubiquitination at DNA double-strand breaks.
NATURE COMMUNICATIONS.
10,
1577
(2018)
The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation.
NATURE COMMUNICATIONS.
9,
3843
(2018)
Kinesin light chain-4 depletion induces apoptosis of radioresistant cancer cells by mitochondrial dysfunction via calcium ion influx.
CELL DEATH & DISEASE.
9,
5
(2016)
Pellino-1 promotes lung carcinogenesis via the stabilization of Slug and Snail through K63-mediated polyubiquitination.
CELL DEATH AND DIFFERENTIATION.
24,
3
(2016)
Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase.
HEPATOLOGY.
63,
1
(2015)
The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.
NATURE COMMUNICATIONS.
6,
(2014)
Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination.
JOURNAL OF CLINICAL INVESTIGATION.
124,
11
Patent/Intellectual Property
Pellino (PELI) 유비퀴틴 접합효소에 의한 중증 건선(Psoriasis)의 새로운 분자표적 발명및 질환동물모델 발굴과 이를 활용한 약제의 개과 평가 방법.
10-2017-0082620.
20191010.
KOREA, REPUBLIC OF
Ssu72을 유효성분으로 포함하는 자가면역질환 예방 또는 치료용 조성물.
10-2016-0038934 .
20171124.
KOREA, REPUBLIC OF
림프종 진단 또는 예후 마커로서 Ｐｅｌｌｉｎｏ 1{Pellino 1 as a marker for the diagnosis or prognosis of lymphoma}.
PA100141KR.
20120907.
PCT
사이클린 의존성 인산화효소의 발현 또는 활성 억제제의 존부를 조절하여 성체 줄기세포와 신경세포 간의 분화를 유도하는 방법 {Method of inducing differentiation of adult stem cells into neural cells by controlling an expression or activity of cyclin-dependent kinases}.
PA100042KR1.
20120813.
PCT
Conference Paper
(2019)
Therapeutic intervention of receptor-mediated ubiquitination signaling
in tumor immunity and autoimmunity.
The 71st Annual Meeting of Korean Society of Pharmacology.
KOREA, REPUBLIC OF
(2019)
Ubiquitination of BCR-mediated signaling protein by Pellino1 in B cell development.
17th International Congress of Immunology.
CHINA
(2019)
Pathogenesis of fatty liver disease by Ssu72-mediated functionality of Kupffer cell.
17th International Congress of Immunology.
CHINA
(2019)
Hypophosphorylation of T cell receptor signaling in regulating the differentiation of peripherally derived regulatory T cells.
World Immune Regulation Meeting XIII.
SWITZERLAND
(2018)
Ssu72 phosphatase regulates tissue-resident macrophage function.
2018 European Congress of Immunology.
NETHERLANDS
(2018)
Regulation of lipid metabolism by Ssu72 phosphatase.
Federation of American Societies for Experimental Biology.
UNITED STATES
(2018)
BCR signaling responsive ubiquitination by Pellino 1 in B cell development.
B Cells: Mechanisms in Immunity and Autoimmunity.
GERMANY
(2018)
Ssu72 phosphatase regulates thermogenesis through macrophage polarization.
American Association of Immunology.
UNITED STATES
(2017)
Signal responsive polyubiquitination monitoring for DNA damage response and pathogenesis.
방사선생명과학회 추계학술대회.
KOREA, REPUBLIC OF
(2017)
A systemic E3 ubiquitin ligase signaling cascade of tumorigenesis and anti-tumor immunity.
암미세환경연구 심포지움.
KOREA, REPUBLIC OF
(2017)
Development of lymphoid tumors by Pellino 1-BubR1 signaling axis which deregulate mitotic spindle checkpoint.
Cold Spring Harbor Symposium.
UNITED STATES
(2016)
Dual Protein Phosphatase Ssu72 in Cellular Lineage and Pathogenesis.
2017 Korean Society of Molecular Cell Biology Cell Cycle Round Table.
KOREA, REPUBLIC OF
(2016)
2016 Internation Conference of the Korean Society for Molecular Cellular Biology
'Symposium 07. Cell Ccyle Control in Diseases' Session Organizor & Chair.
2016 Internation Conference of the Korean Society for Molecular Cellular Biology'Symposium 07. Cell Ccyle Control in Diseases' Session Organizor & Chair.
KOREA, REPUBLIC OF
(2016)
Pellino 1 E3 Ubiquitin Ligase Affecting Cell Cycle Control and Pathogenesis.
2016 KSMCB Cell Cycle Symposium.
KOREA, REPUBLIC OF
(2016)
Potential Coupling of Ssu72 Phosphatase-Mediated Cell Cycle Control with T Cell Immunity.
2016 Korean Society of Molecular Cell Biology Cell Cycle Symposium.
KOREA, REPUBLIC OF
(2015)
2015 KSMCB Cell Cycle Symposium에서 'Ssu72 Protein Phosphatas in Cell Cycle-Related Pathogenesis'주제로 초청 강연함.
2015 KSMCB Cell Cycle Round Table Symposium.
KOREA, REPUBLIC OF
(2015)
2015 East Asia Joint Symposium 에서 'SSU72 function as a gatekeeper monitoring for chromosome integrity' 주제로 발표함.
2015 East Asia Joint Symposium.
JAPAN
(2015)
The 74th Annual Meeting of the Japanese Cancer Association의 International Session 1 'Molecular ground for chromosomal instability'에서 'The Role of Ssu72 Protein Phosphatase in Regulating Chromosome Cohesion and Ploidy'주제로 강연함.
The 74th Annual Meeting of the Japanese Cancer Association (일본암학회 학술대회).
JAPAN
(2015)
2015 Internation Conference of Korean Society of Molecular and Cell Biology 심포지움에서 'BEX protein attenuates the mitotic checkpoint and induces preneoplastic aneuploidy'이란 내용의 연구결과를 초록으로 발표함.
2015 Internation Conference of Korean Society of Molecular and Cell Biology.
KOREA, REPUBLIC OF
(2015)
2015 International Conference of the KSMCB 'Functional role of Pellino 1 in lung cancer tumorigenesis' 연구결과에 대해서 발표함.
2015 International Conference of the KSMCB.
KOREA, REPUBLIC OF
